Andrea De Luca, MD graduated in medicine in 1989 and specialized in Infectious Diseases in 1993. He is an assistant Professor of Infectious Diseases, at the Catholic University of Sacred Heart, Rome, Italy. He is also the Director of the Infectious Diseases Clinic, University Hospital, Siena, Italy. Dr. De Luca is a member of the Scientific Committee, of the Italian Cohort I.Co.N.A of HIV-infected patients, of the Master and ARCA cohorts. He is chair or member of the organising committee of the programme committee of several european and international workshops and conferences on HIV. Dr De Luca has published more than 160 scientific papers cited in PubMed with a sum of Impact Factor (ISI-SCI 2007) of over 800. He has made over 400 presentations at national and international conferences and is author of several chapters on Textbooks of Infectious Diseases. He has been Principal Investigator in several clinical studies performed in GCP. The research activity of dr De Luca has focused mainly on -Clinical studies on the treatment of HIV infection (efficacy, toxicity, adherence) and hepatitis co-infections -Genotypic and phenotypic HIV drug resistance, pharmacokinetics and pharmacogenomics of antiretrovirals -HIV-associated central nervous system disorders, including PML. Dr De Luca has helped developing pilot programs for the introduction of antiretroviral treatment in resource-limited countries and is consultant at WHO for the HIV drug resistance network.