Michael Lederman, MD is the Scott R. Inkley Professor of Medicine at Case Western Reserve University School of Medicine and University Hospitals/Case Medical Center where he is also Professor of Biomedical Ethics, Pathology, Microbiology and Molecular Biology. Dr. Lederman received his bachelor’s degree in Biology from Brandeis University and his M.D. from the Mt. Sinai School of Medicine. He trained in Internal Medicine at Case Western Reserve University, University Hospitals of Cleveland and the VA Medical Center where he served as chief resident in Medicine and completed fellowship training in Infectious Diseases. He received post-doctoral training in cellular immunology in the laboratory of Dr. Jerrold Ellner and he joined the faculty at Case in 1980. Dr. Lederman has been engaged in HIV/AIDS research since he and Dr. Oscar Ratnoff first described and characterized the occurrence of AIDS-related immune deficiency in otherwise healthy men with hemophilia in 1983. He has authored more than 300 peer-reviewed scientific publications largely focused on the mechanisms whereby HIV infection induces immune deficiency and on strategies to correct and prevent it. In 1985, Dr. Lederman established the Special Immunology Unit at University Hospitals of Cleveland that was the first dedicated HIV clinic in Northern Ohio. In 1987, he established the AIDS Clinical Trials Unit at Case/University Hospitals and within the national network of these units, the AIDS Clinical Trials Group (ACTG), he established and directs the network of Immunology Support Laboratories that provides immunologic monitoring of national HIV treatment trials. In the more recent reorganization of the AIDS Clinical Trials Group, he was elected chairman of the Inflammation and End Organ Disease Transformative Science Group that is charged with targeting the morbid complications of HIV infection that are linked to immune activation and inflammation. Dr. Lederman is a member of the Association of American Physicians, the American Association of Immunologists, the Infectious Diseases Society of America, the HIV Medicine Association and is a Fellow of the American Association of Microbiology and the American Association for the Advancement of Science. He serves on the editorial boards of several research journals, and is a member of the Scientific Advisory Boards for the Forum for Collaborative Research and the Agence Nationale de Recherche sur le SIDA (ANRS). He has trained more than two dozen graduate students and post-doctoral fellows, four of whom have been named as the best young researchers in their fields.