Paul McLaren, PhD

Dr Paul McLaren received his PhD the University of Manitoba for work focusing on transcriptional profiling, gene-network analysis and immune function in individuals highly exposed to HIV that remain uninfected. He then preformed his research fellowship in the Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School and the Medical and Population Genetics Program at the Broad Institute. His primary research focus there was on elucidating the genetic mechanisms for the complex traits of HIV-1 viral control and resistance to infection by HIV-1. Dr McLaren was the co-leader of the analysis team on the Genome-wide association study (GWAS) component of the International HIV Controllers Study and the primary analyst on the GWAS of HIV-1 resistance in the Pumwani commercial sex-workers cohort. In Dr McLaren’s current position as Group Leader in Bioinformatics in the department of Microbiology at the Lausanne University Hospital and the Global Health Institute at École Polytechnique Fédérale du Lausanne, his research focuses on the role of rare genetic variation in modifying HIV outcome as identified through next-generation sequencing projects. Additionally, Dr McLaren supervises multiple functional transcriptomic projects aimed at gaining a clearer understanding of multiple stages of the HIV/host cell interaction.