Shuping Tong, MD,PhD

Shuping Tong, M.D.; Ph.D., received his M.D. from Shanghai Medical University in 1983. The same year he started his Master’s Degree study with Professor Yu-mei Wen at Shanghai Medical University and entered into the field of hepatitis B virus (HBV) research. He obtained his Ph.D. from Claude Bernard University in Lyon, France in 1992 under the mentorship of Professor Christian Trepo at INSERM U271. Dr. Tong then moved to Boston where he had his postdoctoral training at the Massachusetts General Hospital of Harvard Medical School. In 1999 he became an assistant professor at Brown University and in 2006 Dr. Tong was promoted to associate professor. Dr. Shuping Tong returned to his Alma mater (now part of Fudan University) at the end of 2012 and became a Tepin  professor at the Medical Molecular Virology lab. In 2014 He became a member of Shanghai’s “thousand talents” program for distinguished overseas Chinese.

While in Lyon Dr. Tong was among the first to discover the precore mutation abolishing HBeAg expression, and was the first to reveal a role of viral genotype in the emergence of precore mutation abolishing HBeAg expression. Subsequently he systemically characterized mutations that modulate HBeAg expression at the transcriptional, translational, and posttranslational levels. His recent research include the comparative analysis of biological properties between HBV genotypes B and C prevalent in China, genotypes A and D common in Western countries, and characterization of virion secretion phenotypes of vaccine escape mutants. Another interest of Dr. Tong is the subviral particles of HBV, which are produced in large excess over infectious virions.

Dr. Tong’s research in the US was supported by the American Cancer Society and National Institutes of Health. He has reviewed for numerous journals for papers dealing with HBV. He currently serves on the editorial boards for Journal of Virology and Journal of Hepatology. He has served numerous times as session chairs for the annual International Molecular Biology of Hepatitis B Viruses Meeting, and had the honor to co-organize the 2013 annual meeting in Shanghai, China at the campus of Shanghai Medical College.