Steven Grinspoon is a Professor of Medicine, Harvard Medical School, Director of the MGH Program in Nutritional Metabolism, and Co-Director of the Nutrition Obesity Research Center at Harvard. He has had a long-standing interest in the metabolic and endocrine complications of HIV disease, with a particular focus on insulin resistance and body composition. He has served on the WHO Technical Advisory Group on Nutrition in HIV Disease and Chaired the AHA State of the Science Conference on Cardiovascular Disease in HIV-infected patients. In addition, he has served as Co-Chair of the Endocrine Society Research Affairs Committee. His work has suggested an increased myocardial infarction rate in HIV-infected patients and highlighted the relative contributions of traditional risk factors, including diabetes and excess visceral fat accumulation, and of nontraditional risk factors, including inflammation and immune activation. He has shown the efficacy of strategies to improve insulin sensitivity and reduce excess visceral fat.