J. Victor Garcia-Martinez received his Ph.D. in Chemistry from Georgetown University. He received postdoctoral training at the NCI and MIT. He was a Research Associate at the Fred Hutchinson Cancer Research Center. He was an Assistant and subsequently an Associate Member of St. Jude Children's Research Hospital and a Professor of Medicine at the University of Texas Southwestern Medical Center. He is currently a Professor of Medicine, Microbiology and Immunology in the Center for AIDS Research, Division of Infectious Diseases, School of Medicine at the University of North Carolina, Chapel Hill. Throughout his career, Dr. Garcia has made seminal contributions to our understanding of HIV pathogenesis in particular to our understanding of the function of Nef, an important determinant of HIV pathogenesis and disease progression. More recently, Dr. Garcia and the members of his group have established an outstanding track record in the development, implementation and use of humanized mice. Since their landmark publication describing the humanized BLT mouse model, it has been widely used to address key questions regarding a variety of aspects of HIV infection, transmission, and prevention.