Brendan Payne is a principle investigator in the Welcome Centre for Mitochondrial Research (WCMR) at Newcastle University, UK. He holds honorary clinical appointments in the Department of Infection and Tropical Medicine and the Department of Microbiology at Newcastle-upon-Tyne Hospitals. His doctoral research was undertaken in the laboratory of Professor Patrick Chinnery, and focussed on the characterisation of somatic mitochondrial DNA mutations in the setting of anti-retroviral therapy. He is actively involved in clinical translational research as well as laboratory studies of the patho-mechanisms of mitochondrial dysfunction in aging. This involves the development of novel histological and molecular techniques to characterise mitochondrial defects. He is particularly interested in the natural history of mitochondrial DNA mutations in aging and how this may be altered, either detrimentally (such as in anti-retroviral treated HIV), or therapeutically. His principle research funder is Wellcome: through a personal fellowship, and as a PI in the WCMR.