Her research has focused on defining the epidemiology of kidney disease among HIV-infected individuals, including those with comorbid risk factors such as Hepatitis C co-infection and diabetes. She also serve as the nephrology consultant for the Mount Sinai Institute for Advanced Medicine, which provides clinical care for more than 10,000 individuals living with HIV infection. This role has allowed her to identify research questions of direct clinical relevance to individuals with HIV infection and kidney disease. Her research has involved productive collaborations with large HIV cohorts, including the VA Aging Cohort Study, the Manhattan HIV Brain Bank Cohort, and the INSIGHT clinical trials network. Dr. Wyatt is the PI on an R01 investigating the potential for kidney injury with oral antiretroviral therapy for HIV pre-exposure prophylaxis. She also directs the clinical core of a longstanding P01 investigating the pathogenesis of HIV-associated nephropathy, and is a co-investigator on a U01 assessing kidney disease risk in first responders to the World Trade Center attack. In addition to original research publications, she has been an invited presenter and moderator at international scientific meetings in HIV and nephrology, and an invited contributor to more than twenty reviews and book chapters on HIV-related kidney disease.