David M. Margolis, MD, is Professor of Medicine, Microbiology and Immunology, and Epidemiology at The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. He obtained his MD in 1985 at the Tufts University School of Medicine.
Dr. Margolis and his laboratory have a long history of translational HIV research involving samples donated by HIV-infected volunteers: investigating basic molecular, virological, and immunological phenomenon, and leveraging insights to develop new interventions in HIV disease. He has studied molecular mechanisms in HIV replication and infection of HIV proviral latency, and defined the role of epigenetic factors in the repression of HIV transcription. Dr. Margolis also has along history of leading diverse, multidisciplinary collaborations that result in the discovery and publication of high-impact work.
More recently, priorities in HIV therapeutics have led Dr. Margolis and his group to revive the study of translational approaches to attack persistent HIV infection. Having worked with the UNC/Duke AHI cohort for the past 5 years, Dr. Margolis herein proposes to perform a critical proof-of-concept study to demonstrate that latent infection can be perturbed by HDAC inhibitors. These studies may define a new and important therapeutic direction and provide important insights into persistent infection that may contribute to efforts to control or eradicate HIV infection.