Dennis Hartigan

Dr. Dennis Hartigan-O'Connor, MD, PhD is an Assistant Professor in the Department of Medical Microbiology and Immunology at UC Davis, as well as a Core Scientist in the California National Primate Research Center.  He is a graduate of Yale College and received M.D. and Ph.D. degrees from the University of Michigan before doing postdoctoral work both in industry and with Mike McCune at UCSF.  Dennis has a longstanding interest in unique features of the infant immune system, particularly developmental features stimulated by the microbiota.  Most recently, he has focused on understanding the variability in T cell compartment maturation in non-human primate infants and the impact of that variability on SIV disease.  His most recent work demonstrates mechanistic links between microbiota and host immune cells, including bacterial metabolites and innate immune receptors such as TLRs.  These mechanisms impact on development of Th17 cells, which Dr. Hartigan-O'Connor showed have an important relationship with SIV disease progression