Diana is a paediatrician, Professor of Epidemiology and Programme Leader of the Paediatric Programme of trials and cohorts at the MRC Clinical Trials Unit. Over the last 30 years she set up and coordinated a network of clinical trials and cohorts across Europe, Thailand and South America mainly addressing questions in paediatric HIV infection within the Paediatric European Network for Treatment of AIDS (PENTA).
Since 1999 her focus has expanded to Africa, and more recently to India. In addition to undertaking large trials addressing strategy questions in adult and paediatric HIV infection, she has more recently widened her focus to include phase 3 trials in childhood tuberculosis and trials in malaria, hepatitis C and antimicrobial resistance. She collaborates widely with clinical and research centres in East and Southern Africa, India, Vietnam and Thailand. Wide inter-disciplinary collaboration with research groups undertaking pharmacology, social and basic science, innovators of medicines for children, and health economists aims to maximise outputs from trials, which aim to have global impact.
Capacity development is an important feature of the overseas collaborations, including interactive courses in paediatric HIV, on-the-ground training in clinical trials and PhD mentorship. She serves on a number of WHO advisory and guideline committees and continues a clinical role at the HIV Family clinic at the Great Ormond Street Hospital for Children in London, which she started in 1991.