Jake Estes, MD

Dr. Jake Estes is a Principal Scientist/Principal Investigator and currently heads both the Retroviral Immunopathology Section and Tissue Analysis Core in the AIDS and Cancer Virus Program at the Frederick National Laboratory operated by Leidos Biomedical Research, Inc.

Dr. Estes' major research aims are focused on i) understanding and further elucidating the biology, mechanisms and barriers to lentiviral mucosal transmission and viral dissemination in order to better guide preventative strategies, and ii) to understand the factors driving systemic immune activation and disease progression to guide adjunctive therapeutic intervention strategies that can be used to ameliorate immune activation and its associated pathologic consequences.

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