Dr. James Kublin is currently Executive Director of the HIV Vaccine Trials Network based at Fred Hutchinson Cancer Research Center. He is also the Medical Director of the Malaria Clinical Trials Center and a faculty member in the Department of Global Health at the University of Washington. Dr. Kublin has conducted extensive research on HIV, TB and malaria, including clinical trials of novel therapies and vaccines. Before moving to Seattle, Jim was Director, HIV Vaccines – Infectious Diseases, for Merck & Co., Inc where he played a key role in the development and implementation of HIV vaccine studies, overseeing the coordination of clinical assays, site identification and development, government and ethical approvals and providing guidance on vaccine policy issues. Jim has a long history in international healthcare having worked with disadvantaged and refugee populations in South and Central America, Southeast Asia and Africa. His interests took him to Malawi where he lived with his family and established several study-sites evaluating anti-malarials and the interactions between HIV and malaria. He was a faculty member at the University of Malawi, College of Medicine, and provided training throughout Africa on epidemiology, malaria, and HIV. Jim completed his B.S. and M.D. at Georgetown University and received his M.P.H. and completed a residency in Preventive Medicine at Johns Hopkins University. Jim continued work in vaccine development and molecular epidemiology while attending the University of Maryland’s School of Medicine for his fellowship in Vaccinology at the Center for Vaccine Development. The Bill and Melinda Gates Foundation awarded Jim a Grand Challenges Exploration award to apply high-throughput system analyses to malaria vaccine development. More recently, Jim is investigating the role of the microbiome in modulating immunes responses in HIV and TB vaccine clinical trials and gnotobiotic mouse models.