Serena is Professor of Neurology and Chief, Division of Neurological Infections and Global Neurology at Yale. Her clinical and translational research explores HIV in the nervous system, focusing on effects of acute HIV infection, antiretroviral treatment, and HIV cure strategies on HIV pathogenesis and persistence in the central nervous system. She collaborates with colleagues of multiple disciplines in clinical studies in urban centers in the United States and in international settings, exploring questions of CNS inflammation, injury, and CNS reservoirs for HIV. She was the first neuroscientist elected to the AIDS Clinical Trials Group (ACTG) HIV Reservoirs and Eradication Transformative Science Group, currently serves on the DHHS Panel on Adult and Adolescent Antiretroviral Treatment Guidelines, and leads multiple projects addressing the pathobiology of NeuroHIV. She also is a neurology clinician who cares for HIV-infected patients with neurological disorders in the Nathan Smith HIV Clinic at Yale.