Wei He, MD

Wei He was born in 1955 in Harbin, Helongjiang Province, PR China and spent his childhood in Hulan County. Till 1972, he completed his learning in primary and high school in Hulan. After six years of social career including as builder and latheman during cultural revolution, he luckily obtained an opportunity to Jiangmushi Medical college to start his medical career. He graduated  with B.M. degree in 1983, subsequently majored in Microbiology in Heilongjiang University of TCM, graduating with M.M. degree in 1987. He then obtained a teaching position at t Heilongjiang University of TCM. From 1991 to 1994, he studied for his M.D. in Heidelberg University in Germany, Faculty of Theoretical Medicine under under the supervision of Professor Dieter Kabelitz. There he worked on studying developmental mechanism of γδT cells, a unique T cell subset, graduating with a M.D. in 1993. In Aug. 1994, he returned to China and joined the laboratory of Professor Denain Ba in Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & School of Basic Medicine, Peking Union Medical College (PUMC). One year later, he obtained a full Professorship in CAMS & PUMC, and got on with His interest in T cells, mainly for human ones. From then on, he obtained a dozen of national and international grants and led his students to embark on the study of γδT cells, focusing on a relationship with tumor-immunology. His group developed expanding γδT cell approach with an immobilized anti-TCRγδ antibody, successively solving a problem that very small quantity of γδT cells in peripheral blood is hardly studied further. They also systemically clarify the biological property and significance of human γδT cells, especially their role in stressful status.
In recent years Wei He has pioneered the structure-biological study in complementarity determining region 3 (CDR3) of human TCRγδ which is binding site for ligand or antigen of TCRγδ. As a result, his group discovered and identified several novel ligands for TCRγδ such as hMSH2, clarified binding mechanism of TCRγδ ligand and found that γδ T cells respond to endogenetic danger message via TCRγδ recognition of ectopically stress-induced antigen γδ. Besides, all these findings have been trying to translate into clinical field.
Wei He is also a major leader in Chinese Society for Immunology (CSI) (2001-present for SG, 2010-present for VP), and represents CSI to participate in affair in International Union of Immunological Societies (IUIS) as the Member, Education Committee of IUIS (2005-present).

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