William DePaolo is an Associate Professor of Medicine at the University of Washington Medical Center, recipient of the Lynn M. and Michael D. Garvey endowed chair in Gastroenterology and Director of UW Center for Microbiome Sciences & Therapeutics (CMiST). Will received his PhD in Immunology & Microbial Pathogenesis from the Feinberg School of Medicine of Northwestern University in 2004. He completed his postdoctoral training at the University of Chicago where he investigated the molecular pathogenesis of Yersinia pestis, while concurrently developing projects investigating immune-modulation within the intestine. Will joined the faculty at the University of Southern California in 2011 as an Assistant Professor in the Department of Molecular Microbiology and Immunology. His current research program broadly aims to understand the relationship between our human cells and the microbiota. Specifically, his laboratory is exploring how perturbations caused by diet, genetics and infection impact the microbiome and using this information to design and test strategies aimed at manipulating the microbiome to treat diseases such as obesity, colon cancer, inflammatory bowel disease and enteric infections.